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The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo

Our findings demonstrate that Ultra-High-Risk groups evidence a similar clinical risk profile when we expand this beyond transition to psychosis

Citation:
Reid AT, Veerati PC, Gosens R, Bartlett NW, Wark PA, Grainge CL, Stick SM, Kicic A, Hansbro PM, Knight DA. Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches. Pharmacol Ther. 2018;185(155-169)

Keywords:
Asthma; COPD; Cystic fibrosis; Epithelium; Goblet cell; Mechanical stress; Monoclonal antibody therapy; Mucus; Signaling pathways; Therapeutic; micro-RNA

Abstract:
Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.