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Research
Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour ImmunosuppressionImmunotherapy has revolutionised the treatment of cancers by harnessing the power of the immune system to eradicate malignant tissue. However, it is well recognised that some cancers are highly resistant to these therapies, which is in part attributed to the immunosuppressive landscape of the tumour microenvironment (TME). The contexture of the TME is highly heterogeneous and contains a complex architecture of immune, stromal, vascular and tumour cells in addition to acellular components such as the extracellular matrix. While understanding the dynamics of the TME has been instrumental in predicting durable responses to immunotherapy and developing new treatment strategies, recent evidence challenges the fundamental paradigms of how tumours can effectively subvert immunosurveillance. Here, we discuss the various immunosuppressive features of the TME and how fine-tuning these mechanisms, rather than ablating them completely, may result in a more comprehensive and balanced anti-tumour response.
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A whole-of-population study of term and post-term gestational age at birth and children's developmentRelative risks of developmental vulnerability for each week of gestation were calculated with adjustment for confounders and addressing missing information.
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Exclusive breastfeeding increased by an internet interventionExclusive breastfeeding for 6 months is acknowledged universally as the optimal feeding method for infants in order to provide the greatest health and...
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The Undiagnosed Diseases Network International: Five years and moreThe Undiagnosed Diseases Network International was established with the major aims of providing diagnoses to patients
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A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsyNew PageThe aim of this study wa to measure activity, participation and QoL in children with CP and to determine how these differ from a comparable group of...
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Responsiveness of the human airway in vitro during deep inspiration and tidal oscillationIn healthy individuals, deep inspiration produces bronchodilation and reduced airway responsiveness, which may be a response of the airway wall to mechanical...
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Responsiveness of the human airway in vitro during deep inspiration and tidal oscillationThe aim of this study was to examine the in vitro response of isolated human airways to the dynamic mechanical stretch associated with normal breathing.
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Elemental carbon exposure and lung function in schoolchildren from Mexico CityThough exposure to air pollution has a detrimental effect on respiratory health, few studies have examined the association between elemental carbon exposure...
Manage procurement of services and the design, development & implementation of a web-based, integrated diabetes patient management system across WA
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Supporting Families ProjectProudly funded by a Telethon Trust Research Grant, the Supporting Families project started in 2024 with the aim of co-designing a new clinical pathway for children with early stage type 1 diabetes (T1D).