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International clinical trial reduced lung inflammation in young kids with cystic fibrosis

Promising results from an Australian-led clinical trial could drastically change the way we care for young children with cystic fibrosis (CF).

Substrate-dependent metabolomic signatures of myeloperoxidase activity in airway epithelial cells: Implications for early cystic fibrosis lung disease

Myeloperoxidase is released by neutrophils in inflamed tissues. MPO oxidizes chloride, bromide, and thiocyanate to produce hypochlorous acid, hypobromous acid, and hypothiocyanous acid, respectively. These oxidants are toxic to pathogens, but may also react with host cells to elicit biological activity and potential toxicity. In cystic fibrosis and related diseases, increased neutrophil inflammation leads to increased airway MPO and airway epithelial cell exposure to its oxidants.

Tracking the impact of early treatment in young children with cystic fibrosis

For decades, cystic fibrosis (CF) meant a life shaped by daily treatments, frequent hospitalisations, and an uncertain future. The arrival of CFTR modulators has changed that picture dramatically, and researchers at the Wal-yan Respiratory Research Centre now want to understand the bigger picture.

Childhood atopy and mental health: a prospective, longitudinal investigation

Findings are the first linking atopy (measured by both parent report and objective verification) with increased vulnerability to affective and anxiety problems

In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice

In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...

Child health a focus in national research grants

The Kids Research Institute Australia researchers have been awarded more than $8 million in prestigious project grants from the NHMRC.

Funding for ground-breaking lung diagnostic technology

The Kids researchers are part of a new collaboration that has secured almost $1million for intensive research into new 4D diagnostic technology to allow accurate assessment of lung function in patients of all ages including the very sick.

Diagnosis of asbestos-related lung diseases

Consideration of the future for asbestos-related lung disease includes screening those at highest risk

No association between in utero exposure to emissions from a coalmine fire and post-natal lung function

Studies linking early life exposure to air pollution and subsequent impaired lung health have focused on chronic, low-level exposures in urban settings. We aimed to determine whether in utero exposure to an acute, high-intensity air pollution episode impaired lung function 7-years later.

An exposome perspective: Early-life events and immune development in a changing world

Here we review the historical origins of exposome research and define a new concept, the metaexposome