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Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness.
The Child Behavior Checklist (CBCL) is a commonly used measure of child and adolescent functioning, which includes seven items that can be aggregated to provide a purportedly valid measure of sleep functioning. The objective of this study was to examine the convergent validity of the CBCL in a paediatric ADHD population and to evaluate the sensitivity of the instrument when benchmarked against the Sleep Disorders Scale for Children (SDSC).
Chronic wet cough in children is the hallmark symptom of protracted bacterial bronchitis (PBB) and if left untreated can lead to bronchiectasis, which is prevalent in Indigenous populations. Underrecognition of chronic wet cough by parents and clinicians and underdiagnosis of PBB by clinicians are known.
Pulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. Research question: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obtained from BAL fluid?
The Opportunity The Oncogenic Signalling Laboratory is a collaborative group composed of clinical and lab-based researchers focused on the goal of
The Opportunity This is an excellent opportunity to work closely with members of the Autism Research Team and CliniKids to assist in the delivery of
The Opportunity You will provide effective and efficient administrative support for the designated researchers and research teams within the AREST CF
identifying mechanisms of cancer development generation of appropriate models of these diseases evaluation of novel therapeutics and translation of discoveries into the clinic
The ORIGINS laboratory Technician will be responsible for daily processing and biobanking of ORIGINS participant blood and other biological samples.
We have multiple positions available in child health research in the areas of asthma, cystic fibrosis, Aboriginal health and following preterm birth.