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BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial

Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to determine whether BCG vaccination protects adults against COVID-19. 

Citation:
Messina NL, Pittet LF, McDonald E, …….. Kollmann T, Lacerda MV, ……. Manning L, Marshall H, …….. Wadia U, Warris A, et al. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial. J Infect. 2024;89(4).

Keywords:
Bacille Calmette-Guérin (BCG) Vaccine; Breakthrough infection; COVID-19; Immunity; Randomised controlled trial

Abstract:
Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to determine whether BCG vaccination protects adults against COVID-19.