Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia

Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes. Gene fusions involving the immunoglobulin heavy chain gene represent a complex and diverse category.

Citation:
Thomson A, Rehn J, Yeung D, Breen J, White D. Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia. npj Precis Oncol. 2025;9(1).

Keywords:
Acute lymphoblastic leukaemia; children's cancers; genomics

Abstract:
Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes. Gene fusions involving the immunoglobulin heavy chain gene represent a complex and diverse category.