Lytic activity, stability, biofilm disruption capabilities and genomic characterisation of two bacteriophages active against respiratory MRSA

This study aimed to characterise bacteriophages for potential therapeutic use against Staphylococcus aureus, focusing on clinical respiratory isolates of methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) strains. Specifically, it sought to evaluate phage lytic activity, host range, stability, biofilm disruption capabilities, and overall safety for therapeutic use.

Citation:
Iszatt JJ, Larcombe AN, Garratt LW, Stick SM, Kicic A. Lytic activity, stability, biofilm disruption capabilities and genomic characterisation of two bacteriophages active against respiratory MRSA. Journal of Applied Microbiology. 2025.

Keywords:
MRSA; Phage; biofilm; resistance; therapy

Abstract:
This study aimed to characterise bacteriophages for potential therapeutic use against Staphylococcus aureus, focusing on clinical respiratory isolates of methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) strains. Specifically, it sought to evaluate phage lytic activity, host range, stability, biofilm disruption capabilities, and overall safety for therapeutic use.