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Boosting the influenza vaccine schedule in children with cancer: a prospective open-label study

Current immunization guidelines recommend one dose of influenza vaccine for children aged ≥9 years and two doses for younger or vaccine-naïve children. However, children receiving chemotherapy have an attenuated immune response. We performed a prospective open-label study in children undergoing treatment for cancer at Perth Children's Hospital, Western Australia, to examine the safety and efficacy of a boosted influenza schedule.

Citation:
Chiu SK, Furlong E, McKinnon EJ, Fox A, ……. Oommen J, Yeoh DK, Cheung LC, Gottardo N, Koetcha RS Boosting the influenza vaccine schedule in children with cancer: a prospective open-label study. npj Vaccines. 2025;10(1).

Keywords:
Influenza; immunisation; children's cancer

Abstract:
Current immunization guidelines recommend one dose of influenza vaccine for children aged ≥9 years and two doses for younger or vaccine-naïve children. However, children receiving chemotherapy have an attenuated immune response. We performed a prospective open-label study in children undergoing treatment for cancer at Perth Children's Hospital, Western Australia, to examine the safety and efficacy of a boosted influenza schedule.