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Impact of Host and Bacterial Metabolism on Antibiotic Susceptibility

Antimicrobial resistance (AMR) is a global healthcare emergency, directly causing 1.3 million deaths per year and predicted to increase dramatically over the coming decades. Understanding the molecular mechanisms underpinning antibiotic resistance is central to approaches for AMR surveillance and diagnosis in a clinical laboratory.

Citation:
Hyatt BL, Rodrigo MKD, Barnett TC. Impact of Host and Bacterial Metabolism on Antibiotic Susceptibility. Biochemistry. 2025;64(23):4555-64.

Keywords:
Antibacterial agents; pharmacology; drug effects; metabolism; infections; microbiology; host-pathogens; sensitivity tests

Abstract:
Antimicrobial resistance (AMR) is a global healthcare emergency, directly causing 1.3 million deaths per year and predicted to increase dramatically over the coming decades. Understanding the molecular mechanisms underpinning antibiotic resistance is central to approaches for AMR surveillance and diagnosis in a clinical laboratory.