Titin-related familial dilated cardiomyopathy: factors associated with disease onset

Truncating variants in the TTN gene (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM) but also occur as incidental findings in the general population. This study investigated factors associated with the clinical manifestation of TTNtv.

Citation:
Johnson R, Fletcher RA, Peters S, …….. Fear V, Ohanian M, et al. Titin-related familial dilated cardiomyopathy: factors associated with disease onset. Eur Heart J. 2025;46(48):5240-57.

Keywords:
Dilated cardiomyopathy; Genetics; Prevention; Risk factors; Titin

Abstract:
Truncating variants in the TTN gene (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM) but also occur as incidental findings in the general population. This study investigated factors associated with the clinical manifestation of TTNtv.