Skip to content
The Kids Research Institute Australia logo

Bifidobacteria support optimal infant vaccine responses

Accumulating evidence indicates that antibiotic exposure may lead to impaired vaccine responses, however the mechanisms underlying this association remain poorly understood. Here we prospectively followed 191 healthy, vaginally born, term infants from birth to 15 months, using a systems vaccinology approach to assess the effects of antibiotic exposure on immune responses to vaccination.

Citation:
Ryan FJ, Clarke M, Lynn MA, ……. McAlister S, Giles LC, …….. Richmond P, Rogers GB, et al. Bifidobacteria support optimal infant vaccine responses. Nature. 2025;641(8062):456-64.

Keywords:
Anti-bacterial agents; adverse effects; pharmacology; immunology; Bifidobacterium; microbiology; drug effects; gastrointestinal microbiome, vaccine; pneumococcal vaccines

Abstract:
Accumulating evidence indicates that antibiotic exposure may lead to impaired vaccine responses, however the mechanisms underlying this association remain poorly understood. Here we prospectively followed 191 healthy, vaginally born, term infants from birth to 15 months, using a systems vaccinology approach to assess the effects of antibiotic exposure on immune responses to vaccination.