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Immune impacts of infant whole-cell and acellular pertussis vaccination on co-administered vaccines

We compared the effect of a heterologous wP/aP/aP primary series (hereafter mixed wP/aP) versus a homologous aP/aP/aP primary schedule (hereafter aP-only) on antibody responses to co-administered vaccine antigens in infants and toddlers.

Citation:
Pérez Chacón G, McAlister S, Totterdell J, Estcourt MJ, Marsh JA, Jones M, Perrett KP, Campbell DE, Wood N, Gold M, Waddington CS, O'Sullivan M, Curtis N, Wadia U, McIntyre PB, Holt PG, Snelling T, Richmond PC. Immune impacts of infant whole-cell and acellular pertussis vaccination on co-administered vaccines. J Infect. 2025;91(1).

Keywords:
Diphtheria-Tetanus-Pertussis Vaccine/immunology; Diphtheria-Tetanus-acellular Pertussis Vaccines; Haemophilus Vaccines; Hepatitis B Vaccines; Pneumococcal Conjugate Vaccine; Vaccines, Combined; Vaccines, Conjugate/immunology

Abstract:
We compared the effect of a heterologous wP/aP/aP primary series (hereafter mixed wP/aP) versus a homologous aP/aP/aP primary schedule (hereafter aP-only) on antibody responses to co-administered vaccine antigens in infants and toddlers.