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Taste-Masked Diclofenac Sodium Microparticles Prepared by Polyelectrolyte Complexation: Formulation Using Different Fatty Acids and Taste Evaluation by Human Panel

Paediatric patients continue to lack access to age-appropriate oral medicines for their treatment and have to depend on the off-label use of medicines approved for adults, which compromises dosing accuracy and exposes children to unpleasant bitterness. 

Citation:
Yoo O, Sultana S, von Ungern-Sternberg BS, Lim LY. Taste-Masked Diclofenac Sodium Microparticles Prepared by Polyelectrolyte Complexation: Formulation Using Different Fatty Acids and Taste Evaluation by Human Panel. Pharmaceutics. 2025;17(11).

Keywords:
Diclofenac sodium; eudragit EPO; fatty acid; lauric acid; myristic acid; palmitic acid; pediatric formulation; polyelectrolyte complex; stearic acid; taste masking

Abstract:
Paediatric patients continue to lack access to age-appropriate oral medicines for their treatment and have to depend on the off-label use of medicines approved for adults, which compromises dosing accuracy and exposes children to unpleasant bitterness.