Personal network inference identifies children at risk of recurrent wheezing and asthma

Wheezing and asthma exacerbations are leading causes of pediatric hospital admissions. Predicting which children will experience persistent exacerbations remains challenging. Prior research has identified immune endotypes in the nasal epithelium of children with acute asthma and wheezing, characterized by varying balances of interferons and inflammatory markers. Notably, children exhibiting low interferon responses coupled with high inflammation are at an increased risk for recurrent respiratory exacerbations.

Citation:
Coleman LA, Khoo SK, Bizzintino JA, Franks K, Prastanti F, Borland M, Le Souëf PN, Hancock DG, Karpievitch YV, Bosco A, Laing IA. Personal network inference identifies children at risk of recurrent wheezing and asthma. J Allergy Clin Immunol. 2026.

Keywords:
Childhood; acute asthma; asthma exacerbation; endotypes; transcriptomics; wheezing

Abstract:
Wheezing and asthma exacerbations are leading causes of pediatric hospital admissions. Predicting which children will experience persistent exacerbations remains challenging. Prior research has identified immune endotypes in the nasal epithelium of children with acute asthma and wheezing, characterized by varying balances of interferons and inflammatory markers. Notably, children exhibiting low interferon responses coupled with high inflammation are at an increased risk for recurrent respiratory exacerbations.