A prospective pharmacokinetic interaction study between rifampicin and fusidic acid for the treatment of staphylococcal infections
Keywords:
Anti-bacterial agents; administration; dosage; therapeutic use; chromatography; drug interactions; fusidic acid; rifampin; staphylococcal infections
Abstract:
Fusidic acid with rifampicin is used for the treatment of severe staphylococcal infection, particularly prosthetic joint infections. Previous studies using twice daily fusidic acid showed rifampicin increases fusidic acid clearance, potentially causing sub-therapeutic concentrations.