Reports and Findings

A Diagnosis for All Rare Genetic Diseases: The Horizon and the Next Frontiers

There is a critical need for the field to develop and implement strategies to understand the mechanisms underlying all rare diseases and translate these to clinical care

Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic Disease

In this concept paper, we discuss multiomic approaches to studying immune dysregulation and highlight some of the challenges and opportunities

Measles

Measles is a highly contagious infectious disease that can cause severe, long-term complications in children.

Childcare Use and Its Role in Indigenous Child Development: Evidence from the Longitudinal Study of Indigenous Children in Australia

Relatively disadvantaged children might benefit more from attending childcare, as indicated by the positive estimated effects found for those who never attended childcare

Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing

Asthma exacerbations in children can be divided into IRF7hi versus IRF7lo phenotypes with associated differences in clinical phenotypes

Wongi mi bardup (doing it our way): Methodologies promoting Aboriginal knowledges and cultural practices for Birthing on Noongar Boodjar

This paper sets out the methodological and theoretical considerations which framed how the Birthing on Noongar Boodjar project was conducted

Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial

To assess the efficacy and adverse events of epicutaneous immunotherapy with a peanut patch among peanut-allergic children

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life

Associations between the home yard and preschoolers’ outdoor play and physical activity

Features of the home-yard physical environment were positively associated with preschoolers’ outdoor play and physical activity

Targeting the bone marrow microenvironment: a novel therapeutic strategy for pre-B acute lymphoblastic leukemia

Our findings shed light on the mechanisms of leukemia-induced bone loss