Systems biology and bile acid signalling in microbiome-host interactions in the cystic fibrosis lung
The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbal…
Lung inflammation and simulated airway resistance in infants with cystic fibrosis
Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estim…
BAL Inflammatory Markers Can Predict Pulmonary Exacerbations in Children With Cystic Fibrosis
Pulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of s…
Coronavirus and Cystic Fibrosis; What Do We Know?
by Dr Shivanthan Shanthikumar
Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus
We tested the hypothesis that treatment of CF epithelial cells with ivacaftor (Iva) or ivacaftor/lumacaftor (Iva/Lum) would improve control of rhinov…