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Frequency, Burden and Pathogens of Acute Respiratory Illness in Very Preterm Infants During Infancy

To describe the frequency, burden, and pathogen profile of acute respiratory illnesses in very preterm infants during the first year after neonatal i…

Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials

Mucus plugs have been previously recognized as an important pathological feature in asthma and chronic obstructive pulmonary disease (COPD), but thei…

ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations

Cystic fibrosis (CF) is a genetic condition caused by mutation of the cystic fibrosis transmembrane regulator (CFTR) gene. Recently licensed modulato…

International Society of Pediatric Respiratory Diseases (INSPiRED) call to action: A Global Ban on Electronic Cigarette Sales to Protect our Children's Future

Electronic cigarettes (e-cigarettes) have become a leading form of nicotine use among children and adolescents worldwide. The World Health Organizati…

When ‘vape-free’ should mean ‘smoke-free’: third-hand e-cigarette residues and the developing lung

E-cigarettes are widely perceived as a safer alternative to tobacco, and that perception often extends to their use around infants and children. Yet…

Advancing equity: six-year respiratory outcomes in young Indigenous children following early respiratory disease detection

Protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) and bronchiectasis are parts of a disease spectrum characterised by ch…

Healthcare professionals’ experiences involving Aboriginal families in the paediatric ESCALATION system

The Western Australian paediatric ESCALATION system, integrating family involvement, promotes early recognition and response to a hospitalised child'…

Chlorinated drinking water exposure enriches antimicrobial resistance pathways in the infant gut microbiome: a randomized trial

Water chlorination is essential for controlling harmful microbes in drinking water; however, the antimicrobial effects of chlorine-based disinfectant…

FEF25–75% trajectories from age 7 to 53 years, associations with childhood and parental preconception factors, and midlife COPD risk: a prospective cohort study

Existing trajectory studies have emphasised large-airway indices, but chronic obstructive pulmonary disease (COPD) might originate in smaller airways…

First global synthesis of heat-related mental health impacts in children and young people: a systematic review and meta-analysis

Climate change is increasing the frequency and severity of non-optimal temperatures and heatwaves, posing risks to public health, especially for chil…