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Research
Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin DUVR or sunlight exposure may be an effective means of suppressing the development of obesity and MetS, through mechanisms that are independent of vitamin D
Research
Dendritic cells and multiple sclerosis: Disease, tolerance and therapyMultiple sclerosis (MS) is a devastating neurological disease that predominantly affects young adults resulting in severe personal and economic impact.
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Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in the bone marrowInjection of BM-differentiated DCs from nonchimeric mice restored the reduced immune responses of PGE2-chimeric mice.
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Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the AbsenceVitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator.
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Modulation of the immune system by UV radiation: More than just the effects of vitamin D?Humans obtain most of their vitamin D through the exposure of skin to sunlight
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Immune mechanisms by which topically applied vitamin D acts as a therapeutic agentVitamin D, nutrition, diet, therapeutic agent
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Narrowband UVB phototherapy reduces TNF production by B-cell subsets stimulated via TLR7 from individuals with early multiple sclerosisAt the end of a 60-day course of narrowband UVB phototherapy, administered to individuals with early multiple sclerosis, there were changes in the relative proportions of circulating B-cell subsets. This study investigated phototherapy-associated changes to cytokine responses of B cells when exposed to a TLR7 ligand.
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Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditionsAlthough genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form does not ameliorate disease. Genetic variation in genes regulating vitamin D, and regulated by vitamin D, affect MS risk.
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Direct infant UV light exposure is associated with eczema and immune developmentThis study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema
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Vitamin D C3-epimer levels are proportionally higher with oral vitamin D supplementation compared to ultraviolet irradiation of skin in mice but not humansThe proportion of 25(OH)D3 that undergoes epimerization is greater with oral vitamin D3 supplementation than exposure to UVR in mice, but not in humans