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Besides the challenges associated with their teenage years, adolescents with Type 1 Diabetes (T1D) encounter additional challenges of having a chronic condition.
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Variation in nutrition education practices in SWEET pediatric diabetes centers-an international comparisonNutrition education is central to pediatric type 1 diabetes management. Dietary management guidelines for type 1 diabetes are evidence based, but implementation may be challenging and inconsistent. We describe variation in the practice of nutrition education across pediatric diabetes centers globally and explore associations with A1c and BMI.
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SGLT2 Inhibitor-Induced Sympathoexcitation in White Adipose Tissue: A Novel Mechanism for BeigingRecent preclinical data show that sodium glucose cotransporter 2 (SGLT2) inhibitors are able to reduce weight gain and induce beiging in white adipose tissue (WAT). We have previously shown that in neurogenic hypertensive Schlager (BPH/2J) mice, treatment with the SGLT2 inhibitor, Dapagliflozin, reduced blood pressure and prevented weight gain. Here we show that chemical sympathetic denervation achieved by systemic administration of 6-hydroxy-dopamine (6-OHDA) reduces body weight and the heightened sympathetic nervous system (SNS) innervation in WAT.
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ApoB48-Lipoproteins Are Associated with Cardiometabolic Risk in AdolescentsAdolescents with polycystic ovary syndrome (PCOS) have increased incidence of cardiometabolic risk factors including dyslipidemia. Atherogenic apolipoprotein (apo) B-lipoprotein remnants are associated with increased cardiovascular disease (CVD) risk.
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Exercising Safely with Type 1 Diabetes – Development of Clinical GuidelinesOur research focuses on what are the best ways for patients with Type 1 Diabetes to exercise safely. We aim to develop clinical guidelines that provide improved advice for patients and educate patients on how to prevent hypos during and after exercise.
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Use of Hybrid Closed Loop therapy in hypoglycaemia awarenessThis study will tell us if the use of a hybrid closed loop system can improve awareness of hypoglycaemia.
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National Hybrid Closed-Loop Outpatient TrialThe national Hybrid Closed-Loop Outpatient Trial will test the use of an automated insulin delivery system to see if it is better at optimising blood glucose levels than standard therapy.
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Western Australian DNA and Longitudinal Serum Bank for Weight RegulationThis resource will allow researchers to carry out studies which will look at the genetic causes of excessive weight gain and identify biomarkers