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Role of innate immunity in the development of allergy and asthmaThe purpose of this review is to examine the role of innate immunity in the lungs in the development of allergy and asthma.
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The hygiene hypothesis revisited: role of materno-fetal interactionsFor 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immu
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UV inhibits allergic airways disease in mice by reducing effector CD4 T cellsIn human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4
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Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epitheliumIn human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4
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Long-term derangement of antigen presenting cell populations in the respiratory tract following Influenza A infectionThis project investigates how different populations of cells within the respiratory tract immune system are altered during a viral infection.
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Prematurity-associated lung disease: is it asthma?Shannon Elizabeth Simpson Smith BMedSci (hons), PhD PhD, MSc, BSc Head, Strong Beginnings Research Program Manager 08 6319 1631 08 6319 1178
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Pertussis immunisation in infancy and atopic outcomes: A protocol for a population-based cohort study using linked administrative dataThe burden of IgE-mediated food allergy in Australian born children is reported to be among the highest globally. This illness shares risk factors and frequently coexists with asthma, one of the most common noncommunicable diseases of childhood.
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ORIGINS Project shines light on Early Childhood DevelopmentA collaboration between The Kids Research Institute Australia and Joondalup Health Campus is poised to be a game-changer for early childhood development.
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Autism likelihood in infants born to mothers with asthma is associated with blood inflammatory gene biomarkers in pregnancyMothers with asthma or atopy have a higher likelihood of having autistic children, with maternal immune activation in pregnancy implicated as a mechanism. This study aimed to determine, in a prospective cohort of mothers with asthma and their infants, whether inflammatory gene expression in pregnancy is associated with likelihood of future autism.
Research
Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association StudiesIn this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research.