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Twenty years of integrated disease surveillance and response in Sub-Saharan Africa: challenges and opportunities for effective management of infectious disease epidemicsThis systematic review aimed to analyse the performance of the Integrated Disease Surveillance and Response strategy in Sub-Saharan Africa and how its implementation has embraced advancement in information technology, big data analytics techniques and wealth of data sources.
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Antimicrobial susceptibility testing profiles of ESBL-producing Enterobacterales isolated from hospital and community adult patients in Blantyre, MalawiThere is a paucity of data on antimicrobial resistance (AMR) in Malawi. Here we present a study of AMR of extended-spectrum β-lactamases-producing Enterobacterales (ESBL-E) isolated from hospital and community settings in Blantyre, Malawi.
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Geospatial modelling for malaria risk stratification and intervention targeting for low-endemic countriesEwan Punam Susan Tasmin Cameron Amratia Rumisha Symons BSc PhD PhD PhD (Biostatistics) Director of Malaria Risk Stratification Honorary Research
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Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burdenTesting and treating symptomatic malaria cases is crucial for case management, but it may also prevent future illness by reducing mean infection duration. Measuring the impact of effective treatment on burden and transmission via field studies or routine surveillance systems is difficult and potentially unethical. This project uses mathematical modeling to explore how increasing treatment of symptomatic cases impacts malaria prevalence and incidence.
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Modelling temperature-driven changes in species associations across freshwater communitiesDue to global climate change–induced shifts in species distributions, estimating changes in community composition through the use of Species Distribution Models has become a key management tool. Being able to determine how species associations change along environmental gradients is likely to be pivotal in exploring the magnitude of future changes in species’ distributions.
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Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malariaIndividual-based models have become important tools in the global battle against infectious diseases, yet model complexity can make calibration to biological and epidemiological data challenging. We propose using a Bayesian optimization framework employing Gaussian process or machine learning emulator functions to calibrate a complex malaria transmission simulator.
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Viral haemorrhagic fevers and malaria co-infections among febrile patients seeking health care in TanzaniaIn recent years there have been reports of viral haemorrhagic fever (VHF) epidemics in sub-Saharan Africa where malaria is endemic. VHF and malaria have overlapping clinical presentations making differential diagnosis a challenge.
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The Centres for Disease Control light trap and the human decoy trap compared to the human landing catch for measuring Anopheles biting in rural TanzaniaVector mosquito biting intensity is an important measure to understand malaria transmission. Human landing catch (HLC) is an effective but labour-intensive, expensive, and potentially hazardous entomological surveillance tool. The Centres for Disease Control light trap (CDC-LT) and the human decoy trap (HDT) are exposure-free alternatives.
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WALLABY pre-pilot survey: Two dark clouds in the vicinity of NGC 1395We present the Australian Square Kilometre Array Pathfinder (ASKAP) WALLABY pre-pilot observations of two 'dark' H i sources (with H i masses of a few times 108 {M}_\odot and no known stellar counterpart) that reside within 363 kpc of NGC 1395, the most massive early-type galaxy in the Eridanus group of galaxies.
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Spatial distribution of rotavirus immunization coverage in Ethiopia: a geospatial analysis using the Bayesian approachRotavirus causes substantial morbidity and mortality every year, particularly among under-five children. Despite Rotavirus immunization preventing severe diarrheal disease in children, the vaccination coverage remains inadequate in many African countries including Ethiopia.