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Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected

Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. Previous studies have been limited by difficulties in obtaining early specimens.

IL-17A-producing γδ T cells suppress early control of parasite growth by monocytes in the liver

This study examines the role of IL-17 in mice infected with L. donovani and discovered an unexpected negative, regulatory role for this cytokine in the...

Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation early development

The predominant occurrence of extragonadal teratomas/teratocarcinomas in human neonates suggests that pluripotent cells are tumour-forming even during...

MS in South Asians in England: Early disease onset and novel pattern of myelin autoimmunity

Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals.

Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a Childhood Leukemia International Consortium study

The associations between childhood acute lymphoblastic leukemia (ALL) and several proxies of early stimulation of the immune system, that is, day-care center...

Factors associated with early cessation of breastfeeding in women with gestational diabetes mellitus

To determine factors associated with early cessation of breastfeeding (≤3 months) in women with recent gestational diabetes mellitus (GDM).

Gene Expression Analyses of the Spatio-Temporal Relationships of Human Medulloblastoma Subgroups during Early Human Neurogenesis

Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality.

Body mass index, adiposity rebound and early feeding in a longitudinal cohort (Raine Study)

This study examined the influence of type and duration of infant feeding on adiposity rebound and the tracking of body mass index (BMI) from birth to 14 years

Early motor development is part of the resource mix for language acquisition -

Early motor development is part of the resource mix for language acquisition - a commentary on Iverson's 'Developing language in a developing body: the relat...

The built environment and early childhood development: qualitative evidence from disadvantaged Australian communities

This paper explores neighborhood-built environment features related to ‘better than expected’ and ‘as expected’ early childhood development outcomes (ECD) in 14 Australian disadvantaged communities. This paper draws from mixed methods data collected in the Kids in Communities Study–an Australian investigation of community effects on ECD–in communities across five states and territories.