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Epithelial Drivers of Neutrophil Plasticity in Early Cystic Fibrosis Lung Disease

Hallmarks of cystic fibrosis (CF) airway disease include bronchiectasis, airway inflammation by infiltrating polymorphonuclear neutrophils (PMNs) and recurring infection.

Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis

Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis Rationale: Recent data show that Aspergillus

Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic Fibrosis Lung Disease

Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic Fibrosis Lung Disease Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic

CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis

CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis CrossTalk opposing view: mucosal

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis Lung inflammation and infection are common

Air trapping in early cystic fibrosis lung disease—Does CT tell the full story?

Air trapping in early cystic fibrosis lung disease—Does CT tell the full story? Abstract Introduction: Mosaic attenuation on expiratory chest

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis Early diagnosis and treatment in

Single-breath washout and association with structural lung disease in children with cystic fibrosis

Single-breath washout and association with structural lungdisease in children with cystic fibrosis Abstract Background: In children with cystic

Lung function changes in children exposed to mine fire smoke in infancy

Chronic, low-intensity air pollution exposure has been consistently associated with reduced lung function throughout childhood. However, there is limited research regarding the implications of acute, high-intensity air pollution exposure. We aimed to determine whether there were any associations between early life exposure to such an episode and lung growth trajectories.

Variants associated with HHIP expression have sexdifferential effects on lung function

Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sexdifferential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.