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Showing results for "Neuromuscular disorders "
As well as ORIGINS long-term core research, there are a number of clinical trials, early interventions and shorter-term research studies that sit within ORIGINS. Known as sub-projects, these studies look at multiple aspects of child and family health and development.
Positive mental health, flourishing, and resilience to stress are not only critical to the overall wellbeing of a person but also their physical health, affecting both chronic and acute health conditions
High-grade glioma (HGG) cells reactivate neurodevelopmental programs regulated by ion channels to drive tumor progression. The activity of voltage-gated sodium channels (VGSCs) is fundamental to development, a target of blood-brain barrier (BBB)-permeable FDA-approved drugs, and aids tumor advancement in several cancers. However, the contribution of VGSC activity to HGG pathology remains unknown.
Glioblastoma, a lethal high-grade glioma, has not seen improvements in clinical outcomes in nearly 30 years. Ion channels are increasingly associated with tumorigenesis, and there are hundreds of brain-penetrant drugs that inhibit ion channels, representing an untapped therapeutic resource. The aim of this exploratory drug study was to screen an ion channel drug library against patient-derived glioblastoma cells to identify new treatments for brain cancer.
To determine the proportion of child maltreatment-related emergency department presentations in WA and describe the types of injuries associated with them.
The maternal experience of stressful events during pregnancy has been associated with a number of adverse consequences for behavioral development offspring...
To determine whether there was an independent effect of breastfeeding on child and adolescent mental health
Child behaviour following low to moderate maternal drinking in pregnancy
Yael Penelope Keely Bep Amy Helen Perry Strauss Bebbington Uink Finlay-Jones Milroy BPsych (Hons) MPsych (Clin) PhD BA, MPH, PhD MClinPsych/PhD
Our aim is to improve the emergency transfer of very ill babies by the NETS WA team such that it better supports parents and enhances infants’ recovery and long-term outcomes.