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Showing results for "Neuromuscular disorders "

Ion channel modulator DPI-201-106 significantly enhances antitumor activity of DNA damage response inhibitors in glioblastoma

Glioblastoma, a lethal high-grade glioma, has not seen improvements in clinical outcomes in nearly 30 years. Ion channels are increasingly associated with tumorigenesis, and there are hundreds of brain-penetrant drugs that inhibit ion channels, representing an untapped therapeutic resource. The aim of this exploratory drug study was to screen an ion channel drug library against patient-derived glioblastoma cells to identify new treatments for brain cancer. 

Western Australian emergency department presentations related to child maltreatment and intentional injury

To determine the proportion of child maltreatment-related emergency department presentations in WA and describe the types of injuries associated with them.

Research outputs

Find out about the research outputs for the Development Pathways Project, and see the published research outcomes.

Antecedents of hospital admission for deliberate self-harm from a 14-year follow-up study using data-linkage

A prior episode of deliberate self-harm (DSH) is one of the strongest predictors of future completed suicide. Identifying antecedents of DSH may inform strategi

Maternal life events during pregnancy and offspring language ability in middle childhood

There is accumulating evidence for a link between maternal stress during pregnancy and later behavioural and emotional problems in children.

Antecedents of teenage pregnancy from a 14-year follow-up study using data linkage

This study identified possible antecedents of teenage pregnancy using linked data from administrative sources to create a 14-year follow-up from a cross-sect...

Development and validation of the Australian Aboriginal racial identity and self-esteem survey for 8-12 year old children (IRISE-C)

In Australia, there is little empirical research of the racial identity of Indigenous children and youth as the majority of the current literature focuses on...

Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms

Pregnancy is a time of vulnerability for vitamin D insufficiency, and there is an emerging literature associating low levels of 25(OH)-vitamin D with...

Morbidity due to acute lower respiratory infection in children with birth defects: A total population-based linked data study

Children with birth defects experience higher rates of hospitalisation for ALRIs before age 2 years than children with no birth defects.

Supporting parents with young children to create healthy screen time behaviours

Screen time is an increasing challenge faced by parents across Australia.