Search
Research
Atopy-dependent and independent immune responses in the heightened severity of atopics to respiratory viral infections: Rat model studiesThe co-exposure responses in the Th2high BN incorporated type I interferon/Th1, alternative macrophage activation/Th2 and Th17 signatures
Research
Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specificChronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear
Research
Epithelial-dendritic cell interactions in allergic disordersAirway epithelial cells act through multiple mechanisms to function as an important component of the pulmonary defence strategy that is crucial...
Research
The impact of Influenza infection during early life on immune developmentThis study will investigate the why disease is worse in infants and how early life viral infection impacts the developing immune system.
Research
Inflammation induces α1-adrenoceptor expression in peripheral blood mononuclear cells of patients with complex regional pain syndromePersistent regional and systemic inflammation may promote pain and hyperalgesia in complex regional pain syndrome. In this study, we investigated whether stimulation of α1-adrenoceptors on peripheral blood mononuclear cells might contribute to this inflammatory state.
Research
Targeting the mucosal immune system in a pregnant mouse model to prevent experimental allergic airways disease in the offspringStudies in Europe show exposure of pregnant women to high levels of microbial products stimulate immune function maturation in their offspring
Research
The cellular effects of estrogen on allergic asthmaThe study aims to identify the mechanism for this so that this knowledge can be used to better treat asthma and allergies in both males and females.
Research
Mechanisms of IgE sensitizationThis project investigates how cells of the immune system respond to substances to cause allergies to help develop new treatments.
Research
Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditionsOne explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern...
Research
Virus infection and allergy in the development of asthma: What is the connection?Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy.