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Research
State transitions across the Strep A disease spectrum: scoping review and evidence gapsThe spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state transitions across the Strep A disease spectrum. We identified 175 articles reporting 262 distinct observations of Strep A disease state transitions.
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Inert 50-nm Polystyrene Nanoparticles That Modify Pulmonary Dendritic Cell Function and Inhibit Allergic Airway InflammationNanoparticles are being developed for diverse biomedical applications, but there is concern about potential to promote inflammation, particularly in the lungs.
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Respiratory viral pathogens associated with lower respiratory tract disease among young childrenAcute lower respiratory tract infections (ALRI) commonly result in fatal outcomes in the young children of Papua New Guinea (PNG).
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Clinical investigation of respiratory system admittance in preschool childrenWe compared the ability of Ars, to standard oscillatory outcomes, to determine respiratory disease and differentiate responses to inhaled bronchial challenges.
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Lung function in African infants: A pilot studyUnsedated infant lung function measures of tidal breathing, MBW, and eNO are feasible in a semi-rural African setting
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Moving beyond behaviour-only assessment: Incorporating biomarkers to improve the early detection and diagnosis of autism spectrum disordersThis paper presents a response to the Camarata (2014) lead article regarding the accuracy and effectiveness of early identification and early intervention...
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Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysisWe think that variants in genes involved in fructose metabolism and ChREBP-FGF21 pathway interacts with SSB intake to exacerbate associations with SSB intake.
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Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predispositionThere is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring.
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Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALLGATA3low ETP-ALL is a novel stem cell-like leukemia with implications for the use of myeloid-derived therapies
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The potential of antisense oligonucleotide therapies for inherited childhood lung diseasesAntisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.