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Temporally restricted activation of IFNβ signaling determines response to immune checkpoint therapy

The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients.

Lung abnormalities do not influence aerobic capacity in school children born preterm

Children born preterm have impaired lung function and altered lung structure. However, there are conflicting reports on how preterm birth impacts aerobic exercise capacity in childhood. We aimed to investigate how neonatal history and a diagnosis of bronchopulmonary dysplasia (BPD) impact the relationship between function and structure of the lung, and aerobic capacity in school-aged children born very preterm.

Bilateral murine tumor models for characterizing the response to immune checkpoint blockade

This protocol describes bilateral murine tumor models that display a symmetrical yet dichotomous response to immune checkpoint blockade

Pregnancy and birth outcomes of mothers with intellectual disability and their infants: Advocacy needed to improve well-being

For mothers with intellectual disability, modifiable risk factors for adverse outcomes need addressing

Technical standards for respiratory oscillometry

The aim of the task force was to provide technical recommendations regarding oscillometry measurement

Social impairments in autism spectrum disorder are related to maternal immune history profile

this study is the first to show an association between immune activation history in the mother and increased ASD symptom severity in children with ASD

Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement

Consensus recommendations are outlined to direct preschool device design, test performance, and data analysis for the MBW technique

Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis

Background: We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease.

Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention

Here, we summarize and discuss findings of randomized clinical trials that have examined the effects of these strategies on short and long-term.

Air trapping in early cystic fibrosis lung disease-Does CT tell the full story?

Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping"