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This study will conduct a detailed lung health assessment in a follow-up of a group of preterm individuals at 19 years of age.
Lung damage in children with CF occurs much earlier than previously thought, and proving this is related to the decline that occurs later will create new paradigms for prevention and treatment.
Alexander David Deborah Larcombe Martino Strickland BScEnv (Hons) PhD BSc PhD PhD Honorary Research Fellow Head, Chronic Diseases Research Head,
We are excited to announce the winners of our inaugural Illuminate Awards
The ultimate goal of ORIGINS is to reduce the rising epidemic of non-communicable diseases through 'a healthy start to life'.
Developmental Origins of Health and Disease
A diet and lifestyle mobile app targeting a critical window in early pregnancy is being introduced to women in the northern suburbs of Perth, hoping to assist with breaking the ‘transmission’ of obesity from one generation to the next.
Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity.
Despite the substantial burden of lung disease throughout childhood in children who were born very preterm, there are no evidence-based interventions to improve lung health beyond the neonatal period. We tested the hypothesis that inhaled corticosteroid improves lung function in this population.
Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.