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Research

Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes: a randomised controlled trial protocol

This is a randomised controlled home trial to test the MiniMed Medtronic 670G system in people with type 1 diabetes aged 12-25 years

Research

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

GWAS analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis suggested shared genetic mechanisms across rhinitis-related traits

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Reduced heart rate variability in a treatment-seeking early psychosis sample

Findings provide preliminary evidence that early psychosis is associated with reduced heart rate variability

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Child-parent agreement on alcohol-related parenting: Opportunities for prevention of alcohol-related harm

Parent non-supply of alcohol and disapproval of use were most important in terms of associations with ever drinking

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Autoimmune antibodies and asbestos exposure: Evidence from Wittenoom, Western Australia

This study is the first to report increased anti-nuclear antibodies positivity among persons exposed exclusively to crocidolite

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Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma

We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII

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Temporal trends and socioeconomic differences in acute respiratory infection hospitalisations in children: an intercountry comparison of birth cohort studies

Admissions for ARI were higher in Western Australia and displayed greater socioeconomic disparities than England and Scotland, where ARI rates are increasing

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Impact of heart disease on maternal, fetal and neonatal outcomes in a low-resource setting

Occult maternal heart disease may be responsible for a substantial proportion of adverse pregnancy outcomes in low-resource settings

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Research Note: Adaptive trials

This Research Note has explored the strengths, risks and potential complexity of adaptive trials

Research

Developmental vitamin D deficiency produces behavioral phenotypes of relevance to Autism in an animal model

Here we investigate these features in an animal model related to autism spectrum disorder - the DVD-deficient rat