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The evolution of clinical trials for infant acute lymphoblastic leukemia

Despite initial improvements in survival of infants with ALL since establishment of the first pediatric cooperative group ALL trials, the poor outcome has...

Antecedents of teenage pregnancy from a 14-year follow-up study using data linkage

This study identified possible antecedents of teenage pregnancy using linked data from administrative sources to create a 14-year follow-up from a cross-sect...

Understanding children and families' hospital experiences

Our research focuses on identifying practical ways to provide trauma-informed care for children and families visiting the hospital.

WATCH: Supporting Your Child at the Hospital webinar

Amanda Zaffino, Gillian Griffiths, Tracey Jewel Constable, and facilitator Prof. Jeneva Ohan

Content Validation of the Communication Inventory Disability–Observer Reported CID-OR

CDKL5 deficiency disorder is a rare and severe developmental and epileptic encephalopathy that has profound effects on communication. It is essential that communication be measured accurately for upcoming gene therapy trials. The Communication Inventory Disability-Observer Reported was developed from a framework of communication derived from parent/caregiver interview data in consultation with disability and communication experts, and after reviewing concepts in existing measures.

Parent/caregiver perspectives of meaningful improvement in functional domains for people with CDKL5 deficiency disorder: a mixed-methods study

CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy. Greater understanding of the smallest meaningful improvements for individuals with CDD in clinical trials and practice is needed for a person-centred approach to treatment efficacy. This study explored how parent/caregivers of people with CDD understood meaningful improvements and described change for priority functional domains including communication, gross motor, fine motor, feeding.

Are preterm birth and intra-uterine growth restriction more common in Western Australian children of immigrant backgrounds? A population based data linkage study

Our findings illustrate the vulnerabilities of children born to foreign women from low and middle-income countries

Establishing a Clinically Relevant Radiation Therapy Method for Preclinical Medulloblastoma Research

Craniospinal irradiation (CSI) is a cornerstone of pediatric brain cancer therapy, yet detailed, reproducible protocols for accurate CSI delivery in preclinical mouse models remain scarce, hindering translational research and the development of radiosensitizing strategies. We aimed to establish a clinically relevant, easily replicable radiation therapy protocol for medulloblastoma mouse models, providing a robust platform for preclinical evaluation of novel therapeutic combinations.

Influence of maternal obesity on the long-term health of offspring

Including immediate implications for pregnancy complications, increasing evidence implicates maternal obesity having a major impact on long term child health.

EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy

Food allergy can have significant effects on morbidity and quality of life and can be costly in terms of medical visits and treatments.