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The influence of moving walls on respiratory aerosol deposition modelling

This work initially examines particle deposition in a Weibull-type geometry, comparing traditional computational fluid dynamics approaches with a novel...

Clinical Predictors of Respiratory Failure in Paediatric Neuromuscular Disorders

This research project is a collaboration between The Kids Research Institute Australia, Muscular Dystrophy Western Australia, Perth Children’s Hospital and Curtin University.

Respiratory research program recruits 400th participant, marking key milestone

In September 2024, the Western Australian Epithelial Research Program (WAERP) reached a significant milestone by recruiting its 400th participant.

Early respiratory viral infections in infants with cystic fibrosis.

Early respiratory viral infections in infants with cystic fibrosis. Abstract Background: Viral infections contribute to morbidity in cystic fibrosis

Study finds high acute respiratory infection risk for vulnerable babies

Pre-term baby

Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants

A multi-country randomized, placebo-controlled trial of the safety, immunogenicity and efficacy of respiratory syncytial virus (RSV) F-protein nanoparticle vaccine was undertaken in 4,636 pregnant women and their infants. RSV F-protein vaccine was safe and immunogenic in the pregnant women inducing anti-F IgG, palivizumab-competing antibodies and RSV neutralizing antibodies that were transferred to the fetus.

Bacillus licheniformis in geogenic dust induces inflammation in respiratory epithelium

We have previously demonstrated that mice exposed to geogenic dust PM10 experienced an exacerbation of inflammatory responses to influenza A virus.

Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes

Genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment

Respiratory and chest wall mechanics in very preterm infants

Data on static compliance of the chest wall (Ccw) in preterm infants are scarce. We characterized the static compliance of the lung and Ccw to determine their relative contribution to static compliance of the respiratory system in very preterm infants at 36 wk postmenstrual age. We also aimed to investigate how these compliances were influenced by the presence of bronchopulmonary dysplasia and impacted breathing variables.

Respiratory oscillometry in infants: present challenges and future opportunities

Despite a high burden of respiratory disease among infants globally, limited options exist for lung function testing in this age group. Tidal breathing techniques such as oscillometry allow for understanding the pathophysiology of diseases that originate early in life, thus providing the opportunity to develop timely prevention and treatment strategies.