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Is early childhood development impeded by the birth timing of the younger sibling?

This study investigated whether the timing of birth of the younger siblings was associated with the risk of the older siblings’ developmental vulnerability in early childhood.

Interpregnancy intervals and adverse birth outcomes in high-income countries: An international cohort study

Most evidence for interpregnancy interval (IPI) and adverse birth outcomes come from studies that are prone to incomplete control for confounders that vary between women. Comparing pregnancies to the same women can address this issue.

Birth prevalence of congenital heart defects in Western Australia, 1990–2016

We describe the birth prevalence and characteristics of congenital heart defects in a geographically defined Australian population. This descriptive, population-based study examined congenital heart defects in live births, stillbirths and pregnancy terminations ascertained by the Western Australian Register of Developmental Anomalies, 1990-2016.

Survival of infants born with esophageal atresia among 24 international birth defects surveillance programs

Esophageal atresia (EA) affects around 2.3-2.6 per 10,000 births world-wide. Infants born with this condition require surgical correction soon after birth. Most survival studies of infants with EA are locally or regionally based. We aimed to describe survival across multiple world regions. We included infants diagnosed with EA between 1980 and 2015 from 24 birth defects surveillance programs that are members of the International Clearinghouse for Birth Defects Surveillance and Research.

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers

We sought to assess whether the trajectory to asthma begins already at birth and whether epigenetic mechanisms, contribute to asthma inception.

Temporal trends in cerebral palsy by impairment severity and birth gestation

Rates of cerebral palsy in Victoria decreased between the mid-1990s and 2009 for neonatal survivors of all birth gestations

Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohorts

Our findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important...

Cardiovascular disease risk factor profiles of 263,356 older Australians according to region of birth

Risk factors for cardiovascular disease (CVD), such as obesity, diabetes, hypertension and physical inactivity, are common in Australia, but the prevalence...

Childhood behavior problems and age at first sexual intercourse: A prospective birth cohort study

Early first sexual intercourse (FSI) is a risk factor for unplanned abstract teenage pregnancy, sexually transmitted infection, and adverse social, emotional...

Hypospadias Prevalence and Trends in International Birth Defect Surveillance Systems, 1980–2010

We report on the prevalence and trends of hypospadias which indicate that the prevalence of hypospadias continues to increase internationally