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We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo

The most urgent areas appear to be to continue monitoring the emergence of novel otopathogens, and the need to develop prevention and preventative therapies

Presence of bacterial otopathogen in the middle ear during ventilation tube insertion was a predictor of children at-risk of repeat ventilation tube insertion

Treatment of chronic suppurative otitis media with topical antibiotics probably results in an increase in resolution of ear discharge compared with boric acid

We are uncertain about the effectiveness of topical antibiotics in improving resolution of ear discharge in patients with chronic suppurative otitis media

Elevated antimicrobial proteins and peptides and cytokines in middle ear effusion are a marker of inflammation and bacterial persistence

PCV10 did not reduce NTHi density in the nasopharynx or middle ear, and was associated with increased pneumococcal nasopharyngeal density

The relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders.

To assess the effectiveness of antibiotics versus antiseptics for people with chronic suppurative otitis media.

To assess the effects of topical antiseptics for people with chronic suppurative otitis media