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DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models.
Epigenetic modifications are associated with hepatic fat accumulation and non-alcoholic fatty liver disease (NAFLD). However, few epigenetic modifications directly implicated in such processes have been identified during adolescence, a critical developmental window where physiological changes could influence future disease trajectory. To investigate the association between DNA methylation and NAFLD in adolescence, we undertook discovery and validation of novel methylation marks, alongside replication of previously reported marks.
Adolescence is a period of developmental risk for eating disorders and eating disorder symptoms.
Bioinformatician role as part of the LIFECYCLE team in the Diabetes and Obesity Research Group at The Kids Research Institute Australia
Nontypeable Haemophilus influenzae (NTHI) strains are responsible for respiratory-related infections which cause a significant burden of disease in...
The Kids Research Institute Australia researchers have been awarded five of eight State Government awards designed to help cover the hidden costs of conducting research.
This exciting new edition includes several new chapters that deliver an even more robust and high quality resource. It examines issues across the life course,..
with Dr Anna Boggiss
This study sought to determine relationships, by gender, between childhood behaviour problems and adolescent risky sexual behaviours and substance use.
Exploring the challenges to mental and physical health fathers face during their transition to parenthood.