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Lung inflammation and simulated airway resistance in infants with cystic fibrosis

Lung inflammation and simulated airway resistance in infants with cystic fibrosis Cystic fibrosis (CF) is characterized by small airway disease; but

Community bands together to improve lung health of Aboriginal children in East Kimberley

September marks the three-month milestone of an intensive health promotion campaign in the East Kimberley region, which aims to raise awareness of the dangers of a chronic wet cough in Aboriginal children.

Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection

The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood.

Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis.

Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis Abstact Rationale: Neutrophils are

Effect of Posture on Lung Ventilation distribution and Associations with Structure in Children with Cystic Fibrosis

Effect of Posture on Lung Ventilation distribution and Associations with Structure in Children with Cystic Fibrosis Effect of Posture on Lung

The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function.

Early disease surveillance in young children with cystic fibrosis: A qualitative analysis of parent experiences

Sensitive measures of early lung disease are being integrated into therapeutic trials and clinical practice in cystic fibrosis (CF). The impact of early disease surveillance (EDS) using these novel and often intensive techniques on young children and their families is not well researched.

Elastase Exocytosis by Airway Neutrophils Associates with Early Lung Damage in Cystic Fibrosis Children

Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage

Finding the optimal regimen for Mycobacteroides abscessus treatment (FORMaT) in people with Mycobacteroides abscessus pulmonary disease

Mycobacteroides abscessus (MABS) is within the non-tuberculous mycobacteria family. It inhabits soil and water, exhibits multi-antibiotic resistance and causes opportunistic lung infections, which may progress to symptomatic MABS-pulmonary disease (MABS-PD) associated with substantial morbidity, increased healthcare utilisation, impaired quality of life and increased mortality. 

Lung structural and functional impairments in young children with cystic fibrosis diagnosed following newborn screening – A nationwide observational study

Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF). We compared lung clearance index (LCI), FEV1, functional and structural lung magnetic resonance imaging (MRI) outcomes in Swiss children with CF diagnosed following newborn screening.