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This report provides an update on the contemporary global and regional policy landscapes relevant to rheumatic heart disease

increased adherence to penicillin prophylaxis is associated with reduced acute rheumatic fever recurrence and a likely reduction in mortality

Direct and indirect effects on pneumococcal carriage post-PCV10 are likely to result in reductions in pneumococcal disease, including in infants too young to be vaccinated

A vaccine that prevents GAS cellulitis and other skin infections, in addition to throat infections, would maximise its value and commercial viability

Population-based primary prevention of ARF through sore throat management may be effective in well-resourced settings like New Zealand

Severe lower leg cellulitis presents a major burden to the health sector and is increasing with an ageing population

Severe lower leg cellulitis recurrences are frequent, and each episode increases the likelihood of subsequent recurrence and length of hospitalization

Improved public health measures targeting bacterial skin infections are needed to reduce this high burden of skin infections in Western Australia

Our findings are crucial in demonstrating that the Northern Territory STS clone is not STX resistant

Health systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease