Cystic Fibrosis Early Surveillance Program
Cystic fibrosis (CF) airway disease is characterized by chronic inflammation, featuring neutrophil influx to the lumen. Airway macrophages (AMs) can…
We characterized the lower airways microbiome using BAL samples obtained from clinically stable CF young children who underwent bronchoscopy and ches…
Our data suggest that FRC PC-CTs are less sensitive than TLC PC-CTs and that FB-CTs have similar sensitivity to PC-CTs in detecting lung disease
The earliest respiratory function assessments, within or close to the neonatal period, consistently show correlations with lung function and with the…
Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality.
the nature of the early CF lung environment triggering the disease. To elucidate early CF pulmonary pathophysiology ... with CF enrolled in the Austr…
Comprehensive scores incorporating clinical, lung function, imaging and laboratory data will become essential in the future for predicting disease pr…
Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target
In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in chil…