Search
Research
Abacavir inhibits but does not cause self-reactivity to HLA-B*57:01-restricted EBV specific T cell receptorsPre-existing pathogen-specific memory T cell responses can contribute to multiple adverse outcomes including autoimmunity and drug hypersensitivity. How the specificity of the T cell receptor (TCR) is subverted or seconded in many of these diseases remains unclear. Here, we apply abacavir hypersensitivity (AHS) as a model to address this question because the disease is linked to memory T cell responses and the HLA risk allele, HLA-B*57:01, and the initiating insult, abacavir, are known.
Research
Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of actionChemotherapy has historically been the mainstay of cancer treatment, but our understanding of what drives a successful therapeutic response remains limited.
Research
Experience of patients with lung cancer and with targeted therapy-related skin adverse drug reactions: A qualitative studyTo explore the experience of non-small-cell lung cancer patients with targeted therapy-related skin adverse drug reactions.
Research
PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding proteinA novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis
Research
Diverse Anti-Tumor Immune Potential Driven by Individual IFNα SubtypesOur data shows that the expression of distinct IFNα subtypes within the tumor microenvironment results in different anti-tumor activities
Research
Understanding acute burn injury as a chronic diseaseThe review will outline evidence of long-term health effects, possible mechanisms linking burn injury to long-term health and current research into burns as a chronic disease
Research
Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in gliomaWe discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII
Research
Timing of excision after a non-severe burn has a significant impact on the subsequent immune response in a murine modelEarly excision of the wound, during the phase of immune down-regulation initiated by the burn, maintains an innate and adaptive immune cell response
Research
Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic ResponseThe functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target
Research
CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipientsCytomegalovirus (CMV) is a common opportunistic infection encountered in renal transplant recipients (RTRs) and may be reactivated without symptoms at any time post-transplant.