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Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

Macrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis, neutrophils are…

Risk factors for group A streptococcal pharyngitis and skin infections: A case control study

Group A streptococcal (GAS) infections can trigger an immune-mediated response resulting in acute rheumatic fever. The role of social and environment…

Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells

Recent evidence suggests that burn patients are at increased risk of hospital admission for infection, mental health conditions, cardiovascular disea…

Asthma and allergies in a cohort of adolescents conceived with ART

Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolesce…

CliniKids and Griffith University partner for autism research

The Kids Research Institute Australia’s CliniKids and Griffith University are excited to announce a new partnership which will help to grow autism re…

ORIGINS 5000 Families Report

ORIGINS released a milestone document this week, celebrating our families.

Blinatumomab as bridging therapy in paediatric B-cell acute lymphoblastic leukaemia complicated by invasive fungal disease

Invasive fungal disease (IFD) remains a challenging complication of treatment for paediatric acute leukaemia. Consensus fungal treatment guidelines r…

Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap

Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features,…

Influenza vaccination among pregnant women in two hospitals in Sydney, NSW: what we can learn from women who decline vaccination

Pregnant women are recognised as being at risk of serious illness from influenza. Despite this, and longstanding national recommendations for vaccina…