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The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation.
The prevalence of vitamin D-containing supplement use was generally low in the Australian population, particularly for single vitamin D supplements
The prevalence of intellectual disability has risen in WA over the last 10 years with most of this increase due to mild or moderate intellectual disability
A population-based, stepped wedge, cluster randomized controlled trial of an enhanced model of early infant primary care
Whilst a disproportionate number of Aboriginal women die from potentially preventable causes, no research has investigated mortality in Aboriginal mothers.
Although antenatal influenza vaccination is an important public health intervention for preventing serious infection in pregnant women and newborns, reported...
Older maternal age is associated with depression, anxiety, and stress symptoms in young adult females
The Wittenoom mining operation has had a disproportionate effect on malignant mesothelioma incidence in the local Aboriginal population
This study aimed to determine the vaccine effectiveness of the southern hemisphere trivalent inactivated influenza vaccine (TIV) in preventing...
This letter to the editor endorses data linkage studies and cites their potential value over other types of epidemiological studies within the field of...