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Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.
Findings provide further proof of concept that pharmacological targeting of airway smooth muscle thickness will be beneficial and may be facilitated by azithromycin
The findings suggest consistency between caregivers in their reports of the difficulties experienced by children with Fetal Alcohol Spectrum Disorder
Systematic comparison of recovered cell types and their transcriptional profiles across the workflows has highlighted protocol-specific biase
Our results support a fundamental assumption that facial sexual dimorphism is an indicator of immune function during the development of facial sexual dimorphism
The study highlights the need for support for parents and carers of young people who engage in self-harm
Diesel engine exhaust exposures were higher in underground miners and had a negative association with their lung function over a single 12-h shift
We have identified previously uncharacterised subsets of IgG3 + B cells and shown them to correlate with autoimmune attacks on the central nervous system
No evidence of tissue tropism was observed, and there was no apparent selective pressure or constraint of emm types
Key barriers to effective management of chronic wet cough are limited training in chronic wet cough management combined with competing complexities