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The efficacy of chimeric antigen receptor (CAR) T cell therapy in solid tumours is limited by immunosuppression and antigen heterogeneity. To overcome these barriers, 'armoured' CAR T cells, which secrete proinflammatory cytokines, have been developed. However, their clinical application has been limited because of toxicity related to peripheral expression of the armouring transgene.
BNIP3 and NIX are the main receptors for mitophagy, but their mechanisms of action remain elusive. Here, we used correlative light EM (CLEM) and electron tomography to reveal the tight attachment of isolation membranes (IMs) to mitochondrial protrusions, often connected with ER via thin tubular and/or linear structures.
The Kids Research Institute Australia is equipped with a diverse range of histology and microscopy equipment and analysis software to facilitate state-of-the-art imaging.
The aim of establishing a local presence is based upon an intention to be by invitation considered as part of the Kimberley group of organisations as well ...
This was a five year grant from the NHMRC to build research capacity in ten Aboriginal researchers
BioSpecs is a flexible service that supports laboratory research by providing expert technical assistance in pre-analytical sample processing and nucleic acid extractions.
The following maps provide a visual insight into how the number and rate of Indigenous suicides varies across different regions of Australia.
Most laboratory equipment at The Kids Research Institute Australia is owned and maintained by the Institute, in order to make this available for use by all staff and students.
A Network comprised of four regional sites to facilitate key medical, research and training activities undertaken in partnership with Aboriginal communities.
The WAACHS regional profiles look at all four volumes of results across the ATSIC regions of Western Australia.