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ORIGINS is Australia's largest longitudinal cohort study of its kind. Following 10,000 WA children from their time in the womb into early childhood, ORIGINS researchers are working to better understand when and why non-communicable diseases develop, and provide solutions for early intervention to ensure every child and family flourishes throughout their lifetime.

Evidence from animal models demonstrate that intrauterine growth restriction (IUGR) alters airway structure and function which may affect susceptibility to disease. Airway inflammation and dysregulated epithelial barrier properties are features of asthma which have not been examined in the context of IUGR.

The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). This review highlights the many roles of complement for

We investigated predictors of nasopharyngeal carriage in Australian Aboriginal and non-Aboriginal children.

A world-leading research team built to tackle malaria has relocated from Oxford University to Western Australia to take advantage of the state’s growing big data talent pool.

Lung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period

This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma

For 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immu

In human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4

Dr Emma de Jong is an Honorary Research Associate at The Kids Research Institute Australia.