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Research

Genetic Manipulation of Group A Streptococcus-Gene Deletion by Allelic Replacement

An optimized, rapid method for creating markerless isogenic mutations that combines Gibson assembly cloning with a new temperature-sensitive plasmid, pLZts

Research

Strengthening health systems to support children with neurodevelopmental disabilities in Fiji—A commentary

Leadership and collaboration has resulted in increased capacity in the Fijian health system to support children with neurodevelopmental disabilities

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Modelling factors for Aboriginal and Torres Strait Islander child neurodevelopment outcomes: A latent class analysis

This study highlights a range of unique profiles that can be used for improving the early development of young Aboriginal children

Research

Impaired T cell proliferation by ex vivo BET-inhibition impedes adoptive immunotherapy in a murine melanoma model

We established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical melanoma model

Research

The Deep Genome Project.

The Deep Genome Project—to deliver the functional biological annotation of all human orthologous genomic elements in mice

Research

Early life determinants of health: Invest early to break the cycle of long-term disadvantage in neurodevelopmental disorders

This chapter discusses the importance of investment in early life determinants of health to break the cycle of long-term disadvantage. This chapter addresses these issues while focussing on neurodevelopmental disorders and their related mental health concerns as the targets at the centre of a biopsychosocial transformation of the health system.

Research

Pre-exposure prophylaxis for HIV prevention during pregnancy and lactation: forget not the women and children

The framework for appropriately identifying and managing at-risk pregnant and lactating women requiring PrEP is poorly defined

Research

Cochrane corner: platinum-induced hearing loss after treatment for childhood cancer

This systematic review shows that children treated with platinum analogues are at risk of developing hearing loss

Research

Functional connectivity of the vigilant-attention network in children and adolescents with attention-deficit/hyperactivity disorder

ADHD patients showed substantially diminished intrinsic coupling for 7 connections and increased coupling for 4 connections