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Asthma exacerbations are heterogeneous conditions that involve the complex interplay between environmental exposures and innate and adaptive immune function
The first few days of life are characterized by rapid external and internal changes that require substantial immune system adaptations. Despite growing evidence of the impact of this period on lifelong immune health, this period remains largely uncharted.
Mesothelioma is characterised by its aggressive invasive behaviour, affecting the surrounding tissues of the pleura or peritoneum. We compared an invasive pleural model with a non-invasive subcutaneous model of mesothelioma and performed transcriptomic analyses on the tumour samples.
In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function.
Cancer immunotherapy has shown impressive results, but most patients do not respond.
The aim of this study was to examine the gene response of white blood cells in severe allergic reactions to identify genes that could be targets to new drugs...
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...
To show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy.
This methodology has significant potential to identify covert interactions between inflammatory pathways triggered by vaccination, and as such may be a...
Michael Serralha is a Research Assistant in the Chronobiology and ORIGINS teams at The Kids Research Institute Australia.