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Macrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis, neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior to chronic infection, suggesting a potential defect in macrophage immunomodulatory function.

Research

The Bacille-Calmette–Guerin (BCG) vaccination remains the primary strategy to prevent severe disseminated TB in young children, particularly in high TB-burden countries such as Ethiopia. Accurate knowledge of vaccination coverage in small geographical areas is critically important to developing targeted immunization campaigns. Thus, this study aimed to investigate the spatiotemporal distributions and ecological level determinants of BCG vaccination coverage in Ethiopia.

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Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome.

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Developmental theory and previous studies support the potential value of prodromal interventions for infants at elevated likelihood of developing autism. Past research has supported the efficacy of parent-mediated prodromal therapies with infants from as early as 7 months. We outline the rationale for implementing interventions following this model from even earlier in development and report on the feasibility of a novel intervention developed following this model of parent-mediated infant interventions.

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Participation in leisure activities is key to the physical and mental health of children and adolescents with disabilities. The Jooay™ mobile app aims to link children and adolescents with disability to participation opportunities in their community.

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There is a paucity of information regarding the profile of entire paediatric endocrine clinics and how they are changing. This study aimed to analyse the clinic profile of the Western Australian tertiary paediatric endocrine outpatient service over 10 years and compare to national and international data.

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A survey of 136 articles published in 2019 (sampled at random) was conducted to determine whether a statement about missing data was included.

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In this The Kids Research Institute Australia subsite, our Rett syndrome research team manages a national and international database of Rett syndrome.

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The Vector Atlas aims to update and create vector species maps and spatial products that improve disease prediction, mitigation and preparedness.

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Pregnancy marks the transition from childlessness to parenthood, and provides an opportunity for parents-to-be to prepare, research and reflect.

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Melissa O'Donnell BPsych (Hons), MPsych, GradDip Ed, PhD Honorary Research Associate Honorary Research Associate Areas of research expertise: Child

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Helen Jenny Leonard Downs MBChB MPH BApplSci (physio) MSc PhD Principal Research Fellow Head, Child Disability +61 419 956 946 08 6319 1763

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Investigators: Tess Fletcher The overarching aim of this proposed research is to explore the limitations of existing alcohol and pregnancy messages

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Matt Prue Stephanie Cooper Hart Trend BCA Marketing, BSc Statistics and Applied Statistics, PhD BSc (Hons) MSc PhD BSc PhD Manager, Biostatistics

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Shakara Yael Bep Liddelow-Hunt Perry Uink BPhil(Hons) BPsych (Hons) MPsych (Clin) PhD BPsych(Hons.), MAppPsy(Clinical), PhD Research Assistant; PhD

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Young Minds Matter is the largest survey of child and adolescent mental health and wellbeing ever conducted in Australia.

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