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Status of research and development of vaccines for Streptococcus pyogenes

Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development

PneuMum: Impact from a trial of maternal pneumococcal vaccination on middle ear disease amongst Indigenous infants

This study was unable to demonstrate efficacy of 23vPPV in pregnancy against the co-primary outcomes of either all-cause infant ear disease.

The 2015 revision of the Jones criteria for the diagnosis of acute rheumatic fever: Implications for practice in low-income and middle-income countries

This article discusses the 2015 revision of the Jones criteria by the American Heart Association for the diagnosis of acute rheumatic fever.

Sore throat: Is it such a big deal anymore?

This review article addresses the driving factors associated with diagnosis and treatment of sore throats caused by Group A streptococcus.

Revision of the Jones Criteria for the Diagnosis of Acute Rheumatic Fever in the Era of Doppler Echocardiography: A Scientific Statement From the American Heart Association

The goal of this statement was to review the historic Jones criteria used to diagnose acute rheumatic fever in the context of the current epidemiology of the disease and to update those criteria to also take into account recent evidence supporting the use of Doppler echocardiography.

Post-infectious group A streptococcal autoimmune syndromes and the heart

ARF is a classical example of an autoimmune syndrome and is of particular immunological interest because it follows a known antecedent infection with group A...

Controlling acute rheumatic fever and rheumatic heart disease in developing countries: Are we getting closer?

Improved opportunities for the primary prevention of ARF now exist, because of point-of-care antigen tests for Streptococcus pyogenes, and clinical decision...

Impact of an Ivermectin Mass Drug Administration on Scabies Prevalence in a Remote Australian Aboriginal Community.

Scabies is endemic in many Aboriginal and Torres Strait Islander communities, with 69% of infants infected in the first year of life.

Susceptibility to acute rheumatic fever based on differential expression of genes involved in cytotoxicity, chemotaxis, and apoptosis

Differences in the immune response, detectable by gene expression, between individuals who are susceptible to ARF and those who are not

Using participatory action research to prevent suicide in Aboriginal and Torres Strait Islander communities

Using a participatory action research approach, the communities were supported to identify the risk factors challenging individuals, families and communities...