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Research
Benchmarking Imputed Low Coverage Genomes in a Human Population Genetics ContextOngoing advances in population genomic methodologies have recently enabled the study of millions of loci across hundreds of genomes at a relatively low cost, by leveraging a combination of low-coverage shotgun sequencing and innovative genotype imputation methods. This approach has the potential to provide abundant genotype information at low costs comparable to another widely used cost-effective genotyping approach-that is, SNP panels-while avoiding potential issues related to loci being ascertained in distantly related populations.
Research
A modular approach to forecasting COVID-19 hospital bed occupancyMonitoring the number of COVID-19 patients in hospital beds was a critical component of Australia's real-time surveillance strategy for the disease. From 2021 to 2023, we produced short-term forecasts of bed occupancy to support public health decision-making.
Research
Rewiring endogenous genes in CAR T cells for tumour-restricted payload deliveryThe efficacy of chimeric antigen receptor (CAR) T cell therapy in solid tumours is limited by immunosuppression and antigen heterogeneity. To overcome these barriers, 'armoured' CAR T cells, which secrete proinflammatory cytokines, have been developed. However, their clinical application has been limited because of toxicity related to peripheral expression of the armouring transgene.
Research
The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondriaBNIP3 and NIX are the main receptors for mitophagy, but their mechanisms of action remain elusive. Here, we used correlative light EM (CLEM) and electron tomography to reveal the tight attachment of isolation membranes (IMs) to mitochondrial protrusions, often connected with ER via thin tubular and/or linear structures.
Research
The usability and feasibility of a self-compassion chatbot (COMPASS) for youth living with type 1 diabetesAlthough it is well established that youth with type 1 Diabetes (T1D) experience high rates of distress, current clinical care is often under-resourced and unable to provide sufficient or timely psychological support. The current study was designed to evaluate the safety, usability and feasibility of 'COMPASS,' a self-compassion chatbot intervention.
Research
Predicting Problem Gambling in Young Men: The Impact of Sports Gambling Frequency and Internalizing SymptomsYoung men aged 18-25 years are at disproportionately increased risk for gambling problems compared to their older or female counterparts. The unique mechanisms that precipitate these problems in this group remain unclear. Data from the largest longitudinal cohort study on Australian men's health (the Ten to Men Study) were used to identify the psychosocial, health-related, and gambling-related behavioral predictors of problem gambling severity in 265 young men aged 18-25 years. Hierarchical multiple ordinal logistic regression analyses found these predictors to explain a moderate proportion of variance in problem gambling severity.
The Health Promotion and Education Research Program, led by Head Professor Donna Cross, combines over 14+ years of cyber safety research, involving over 30 projects investigating young people’s online behaviours, totalling over $5 million in funding since 2007.
Cyberbullying is when an individual or a group repeatedly uses Information and Communication Technologies (ICT) to intentionally fear, distress, or harm to another person, who finds it hard to stop it from happening.
News & Events
Nine-year-old Beau cuts his curls to fight cancerMeet Beau Jones. Beau is nine-years-old and lives in Eaton where he likes playing basketball and hanging out with his brothers. He’s also passionate about standing up to cancer!
News & Events
Some heroes wear capes. Some heroes wear lab coats. And some heroes wear school uniforms, just like you!Ten-year-old Isabelle decided to make and sell loom band bracelets to raise money for The Kids Research Institute Australia.